Every TTL term, in plain language.

AMH #amh

Anti-Müllerian Hormone — a blood marker of ovarian reserve in women.

AMH falls as the ovary ages and is one of the most useful single signals for where someone sits on the perimenopause-to-menopause arc. Trended over time, it is more informative than any single value.

Bedrock #bedrock

Sleep, stress, training, and nutrition — the foundation under any longevity protocol.

TTL is bedrock-first: before any supplement, peptide, hormone, or frontier modality, the bedrock layer has to be doing its job. Most "stalled" plans we see are bedrock problems wearing modality clothes.

Biomarker #biomarker

A measurable signal in blood, urine, saliva, or a wearable that reflects something about your physiology.

Estradiol, total testosterone, hsCRP, ApoB, fasting insulin, HRV, resting heart rate, sleep stages — all biomarkers. TTL tracks 50+ over time so trend matters more than any single reading.

Codex #codex

TTL’s whole-body balance score across hormones, metabolism, immune, gut, and brain. Updates as your data updates.

The Codex is a dual score: today’s state and a plan-optimized state, with a "next-best actions" delta showing what would move you fastest. It is a signal, not a diagnosis.

FSH #fsh

Follicle-Stimulating Hormone — a brain-to-ovary signal that rises as the ovary slows.

In women, persistently elevated FSH is one of the markers used to identify menopause transition. It is read alongside estradiol and AMH, not in isolation.

GLP-1 #glp-1

Glucagon-Like Peptide-1 receptor agonist. The class includes semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and the upcoming retatrutide.

GLP-1s mimic a gut hormone that tells the brain you are full and the pancreas to release insulin. They drove a major shift in metabolic medicine. The trade-off: muscle loss, side-effect ramps, and rebound when stopped without a bedrock plan.

HRT #hrt

Hormone Replacement Therapy. For women in perimenopause and beyond: estradiol, progesterone, and sometimes a women’s dose of testosterone.

Started in the right window (typically under 60 or within 10 years of menopause for symptomatic women), current evidence supports HRT as a longevity tool — bone, brain, heart, and energy. The prescribing decision sits with a qualified clinician.

LH #lh

Luteinizing Hormone. Triggers ovulation in women and signals the testes to produce testosterone in men.

Longevity #longevity

Healthspan, not just lifespan. Adding good years, not just years.

TTL frames every intervention through the longevity lens: not "what does this do today?" but "what does this do at year 10, year 20, year 30?"

Menopause #menopause

The point where a woman has gone 12 months without a period. Average age is 51 in the United States.

Perimenopause is the years leading up to it; postmenopause is everything after. The hormonal landscape, lab patterns, and protocol decisions are different at each stage.

Peptide #peptide

A short chain of amino acids. The same building blocks as proteins, just smaller and more specific.

Peptides signal the body to repair, recover, or regulate hormones. Common names include BPC-157 (gut/joint repair), TB-500 (recovery), GHK-Cu (skin/wound healing), and the GLP-1 family. Regulatory status varies — TTL surfaces it, the prescribing decision belongs to a clinician.

Perimenopause #perimenopause

The transition years before periods stop. Hormones get noisy first; symptoms can begin a decade before the final period.

Perimenopause is often where the highest-leverage HRT decisions get made — the window matters. Symptoms may appear long before any single lab value crosses a threshold.

Pyramid #pyramid

TTL’s tier model. Bedrock at the base, then foundation supplements, then optimization, then advanced modalities, then frontier.

A plan is built bottom-up: never frontier-first. The pyramid keeps the order honest so you don’t buy peptides while skipping sleep.

SHBG #shbg

Sex Hormone-Binding Globulin. A liver-made protein that binds testosterone and estradiol; affects how much "free" hormone is bioavailable.

Low SHBG often shows up alongside insulin resistance; high SHBG can mask a meaningful free-testosterone deficit. SHBG is read with total + free testosterone, never alone.

Testosterone #testosterone

The primary male androgen. Women have it too, at roughly a tenth of male levels — and it matters for libido, mood, and lean mass at every age.

TRT #trt

Testosterone Replacement Therapy. For men with clinically low testosterone, fatigue, low libido, or stalled body composition.

Common forms: weekly intramuscular or subcutaneous injection, daily transdermal cream, or pellets. Dosing, ancillaries (HCG, anastrozole), and follow-up cadence are clinician decisions.

Wearable #wearable

A device — Apple Watch, Oura, Whoop, Garmin, Fitbit — that streams continuous physiology to your plan.

TTL reads HRV, resting heart rate, sleep stages, training load, and step count from the wearable you already wear. You don’t need a new device.

Missing a term? Email hello@ttlongevity.com and we’ll add it.